SPRAVATO®
Spravato® offers a breakthrough for those who haven’t found relief through traditional antidepressants. As an FDA-approved nasal spray for treatment-resistant depression, Spravato® works differently than standard medications, targeting unique brain pathways to provide rapid and transformative results under expert medical supervision.
Spravato® for Treatment-Resistant Depression
Spravato® (esketamine) is a prescription nasal spray, used along with an oral antidepressant, for adults with treatment-resistant depression (TRD). It is the first FDA-approved medication in a new class of antidepressants that works by targeting the N-methyl-D-aspartate (NMDA) receptor in the brain.
Unlike traditional antidepressants (SSRIs or SNRIs) that can take weeks or months to show results, Spravato® has been shown to improve symptoms in as little as 24 hours for some patients. Because of its unique delivery and potential side effects like dissociation or temporary blood pressure elevation, it must be administered in a certified clinical setting like East Texas Psychiatry.
Our Tyler clinic is a certified Spravato® treatment center, providing a safe, comfortable environment for your 2-hour observation periods under the care of our specialized psychiatric team.
See If Spravato® Is Right For You →How Spravato® Works
Beyond Serotonin
While standard meds focus on serotonin or norepinephrine, Spravato® targets glutamate to help restore brain connections.
Rapid Synaptic Growth
Esketamine helps trigger the growth of new synapses (neural connections), essentially "rewiring" the brain's mood centers.
TRD Specialized
Designed specifically for those who have failed two or more adequate antidepressant trials (Treatment-Resistant Depression).
Observed Safety
Administered only by healthcare providers in REMS-certified clinics to ensure patient safety and monitoring of Spravato®.
Clinical Indicators for Spravato®
Qualifying Criteria
- Diagnosis of Major Depressive Disorder (MDD)
- Failure of 2+ different antidepressant classes
- Persistent feelings of hopelessness or sadness
- Suicidal ideation with intent (MDSI protocol)
- Inability to function in daily life due to mood
- Minimal relief from Psychotherapy alone
- Over 18 years of age
What to Expect During Spravato® Treatment
- In-office self-administration (nasal spray)
- 2-hour monitoring period post-dose
- Comfortable, quiet treatment rooms
- Regular vital sign checks (blood pressure)
- No driving until the day after treatment
- Initial induction phase (2 sessions per week)
- Long-term maintenance (weekly or bi-weekly)
The Spravato® Journey
Consultation
A deep-dive Psychiatric Evaluation to review your medication history and insurance eligibility for Spravato®.
Induction (Weeks 1-4)
Treatment twice a week. This phase focuses on rapid stabilization and beginning the neuro-restoration process.
Maintenance (Week 5+)
Reduced frequency (once weekly or bi-weekly) to sustain the mood improvements and prevent relapse.
Why Choose East Texas Psychiatry
REMS Certified
Fully compliant with FDA safety protocols and certified to provide Spravato® treatment.
Patient Comfort
Dedicated treatment suites designed for relaxation and sensory management during your sessions.
Integrated Care
We combine Spravato® with ongoing Medication Management for comprehensive health.
Insurance Support
Our team works directly with your provider to navigate the prior authorization process for Spravato®.
Take the first step towards lasting wellness, with East Texas Psychiatry and Counseling
Book an Appointment
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Common Questions About Spravato® Treatment
Traditional SSRIs increase serotonin levels between neurons. Spravato® targets glutamate receptors to help restore synaptic connections in brain regions affected by depression, often resulting in much faster relief.
FDA guidelines require medical monitoring for at least 2 hours to watch for side effects of Spravato® like dissociation (feeling "out of it"), dizziness, or a temporary increase in blood pressure. We ensure you are safe and stable before you leave.
No. After using Spravato®, you must have a pre-arranged ride home with a friend, family member, or transport service. You should not drive or operate machinery until the day after your session following a restful sleep.
Most insurance providers cover Spravato® for Treatment-Resistant Depression. Our team handles the prior authorization process for you to confirm your coverage for Spravato® therapy.
The Spravato® induction phase is typically two sessions per week for four weeks. If you respond well, you will move to a maintenance phase, usually once a week or every other week, depending on your clinical needs.
Break Through Treatment-Resistant Depression with Spravato®
If traditional antidepressants haven't worked, Spravato® might be the answer you've been searching for. Take the first step toward a brighter future today with our specialized team in Tyler, TX.
Schedule Your Spravato® Consultation